September 1, 2001European Heart Journal SupplementsOpen Access

Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs

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Population

Cloned cardiac potassium channels expressed heterologously in HEK 293 cells, mouse L cells, and Xenopus…

Design

Preclinical

Authors

ALAntonio E. LacerdaCharles River Laboratories (United States)

Discussion

Member takes

Implication

Supports cloned HERG assays for preclinical QT-risk prediction; leaves open clinical translation.

Structured PICO

Population

Cloned cardiac potassium channels (HERG, MinK/KvLQT1, Kv4.3, Kv1.5) expressed heterologously in HEK 293 cells, mouse L cells, and Xenopus laevis oocytes

Intervention

Six non-antiarrhythmic drugs from four classes (antihistamines, anti-psychotics, antibiotics, prokinetics), including terfenadine, sertindole, and cisapride

Outcome

IC50 values for block of repolarizing cardiac potassium currents (IKr, IKs, ITo, IKur)surrogate

Cloned HERG channel assays are robust preclinical predictors of QT-prolonging proarrhythmic risk for non-antiarrhythmic drugs.

Cite This Study

Antonio E. Lacerda (2001) studied this question.

synapsesocial.com/papers/6a72633afebe604dd70a9440 https://doi.org/10.1016/s1520-765x(01)90003-3

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Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of block among cloned cardiac potassium channels by non-antiarrhythmic drugs

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider