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Glycyrrhizin and its analogues were screened for antihepatotoxic activity by in vitro assay methods using carbon tetrachloride (CCl 4 )-and galactosarnine-induced cytotoxicity in primary cultured rat hepatocytes. Structure-activity relationship in these substances is discussed. The mechanism of inhibitory activity of glycyrrhizin and glycyrrhetinic acid in CCl 4 -produced liver damage was investigated by determining the effects of these substances on the initial steps in the sequence of events leading to liver lesion, revealing that anti-oxidative action plays an important part in the antihepatotoxic activity. 1 Liver-protective drugs, Part 14. Also Part 65 in the Tohoku University series on the validity of Oriental medicines.
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Kiso et al. (1984) studied this question.
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