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September 15, 1993Proceedings of the National Academy of SciencesOpen Access

Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia.

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Why the study?

Does combined antisense cdc2 kinase and PCNA ODN delivery prevent neointima formation in a rat carotid balloon-injury model?

Population

Rat carotid balloon-injury model and in vitro vascular smooth muscle cells

Comparison

Single intraluminal delivery of combined… vs Sense controls, antisense cdc2 kinase ODNs…

Design

Preclinical

Follow-up

up to 8 weeks

Authors

RMRyuichi MorishitaVascular / Pulmonary VascularGGGary H. GibbonsGeneral / Preventive / LipidsKEKristin EllisonUniversity of Kentucky

Discussion

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Implication

No clinical translation yet; leaves open whether antisense ODN efficacy extends from rat models to human restenosis prevention.

Structured PICO

Does combined antisense cdc2 kinase and PCNA ODN delivery prevent neointima formation in a rat carotid balloon-injury model?

P
Population
Rat carotid balloon-injury model and in vitro vascular smooth muscle cells
I
Intervention
Single intraluminal delivery of combined antisense cdc2 kinase and proliferating-cell nuclear antigen (PCNA) oligonucleotides (ODNs) via Sendai virus-liposome complex
C
Comparator
Sense controls, antisense cdc2 kinase ODNs alone, or PCNA ODNs alone
O
Outcome
Neointima formation at 2 and 8 weeks after angioplastysurrogate

Combined antisense oligonucleotide therapy targeting cdc2 kinase and PCNA effectively prevents neointimal hyperplasia in a rat model of balloon angioplasty injury.

Cite This Study

Morishita et al. (1993) studied this question.

synapsesocial.com/papers/6a7265b984cc45bb7be01d82https://doi.org/10.1073/pnas.90.18.8474
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Also Consider

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  1. 1Production of transforming growth factor beta 1 during repair of arterial injury.1991 · 533 citations
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  3. 3Novel and effective gene transfer technique for study of vascular renin angiotensin system.1993 · 105 citations
  4. 4Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury1989 · 1,060 citations
  5. 5Vascular injury induces angiotensinogen gene expression in the media and neointima.1993 · 138 citations