June 6, 2019Frontiers in MicrobiologyOpen Access

Calicivirus RNA-Dependent RNA Polymerases: Evolution, Structure, Protein Dynamics, and Function

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Why the study?

Studying calicivirus RNA-dependent RNA polymerases during viral replication is hampered by a lack of suitable model systems and difficulties propagating viruses like enteric caliciviruses and RHDV in cell culture.

Population

Caliciviridae family RNA-dependent RNA polymerases

Design

Review

Authors

ESElena SmertinaCSIRO Health and Biosecurity NUNadya UrakovaEuropean Bioinformatics Institute TSTanja StriveCSIRO Health and Biosecurity

Discussion

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Implication

RdRp studies in caliciviruses may inform antiviral strategies; leaves open targeted applications in human norovirus.

Structured PICO

Population

Caliciviridae family viruses (including Norovirus, Nebovirus, Sapovirus, Lagovirus, and Vesivirus) and their RNA-dependent RNA polymerases (RdRps)

This review summarizes the structural dynamics, biochemical properties, and functions of calicivirus RNA-dependent RNA polymerases, which are critical for viral replication.

Cite This Study

Smertina et al. (2019) studied this question.

synapsesocial.com/papers/6a726711e5469ee92be26575 https://doi.org/10.3389/fmicb.2019.01280

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Calicivirus RNA-Dependent RNA Polymerases: Evolution, Structure, Protein Dynamics, and Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Calicivirus RNA-Dependent RNA Polymerases: Evolution, Structure, Protein Dynamics, and Function

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider