Why the study?
Does the angiotensin-converting enzyme inhibitor SQ 20,881 alter the response of plasma renin activity, aldosterone, and cortisol to tilting in normal subjects?
Does the angiotensin-converting enzyme inhibitor SQ 20,881 alter the response of plasma renin activity, aldosterone, and cortisol to tilting in normal subjects?
Administration of the ACE inhibitor SQ 20,881 significantly increases plasma renin activity without affecting aldosterone or cortisol levels during postural changes in normal subjects.
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Hypothesis-generating for ACE inhibitor effects on PRA in normals; leaves open relevance in patients with cardiovascular disease.
1 The effect of an angiotensin-converting enzyme inhibitor (SQ 20,881; 0.5 mg/kg) on the response to tilting of plasma renin activity (PRA), plasma aldosterone and cortisol was studied in five normal subjects. 2 PRA rose significantly in both the supine and upright positions following administration of SQ 20,881; no significant effect on aldosterone or cortisol was observed.
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Collier et al. (1974) studied this question.
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