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May 4, 1978New England Journal of Medicine

Antihypertensive Effect of the Oral Angiotensin Converting-Enzyme Inhibitor SQ 14225 in Man

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Why the study?

Does SQ 14225 reduce blood pressure in hypertensive patients refractory to traditional medical therapy?

Population

12 hypertensive patients refractory to traditional medical therapy

Design

Case_series

Follow-up

3 to 24 weeks

Authors

HGHaralambos GavrasGeneral / Preventive / LipidsHBHans R. BrunnerGeneral / Preventive / LipidsGTG. A. TuriniUnited States Department of Veterans Affairs

Discussion

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Implication

Supports further study of oral ACE inhibition in refractory hypertension; should not yet change practice.

Structured PICO

Does SQ 14225 reduce blood pressure in hypertensive patients refractory to traditional medical therapy?

P
Population
12 hypertensive patients refractory to traditional medical therapy
I
Intervention
SQ 14225 (oral angiotensin converting-enzyme inhibitor) 400 to 1000 mg daily
O
Outcome
Blood pressure reductionsurrogate

SQ 14225 is an effective oral ACE inhibitor that significantly lowers blood pressure in patients refractory to traditional therapy.

Cite This Study

Gavras et al. (1978) studied this question.

synapsesocial.com/papers/6a7d3de22935e92dbc775e34https://doi.org/10.1056/nejm197805042981803

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Angiotensin Converting Enzyme Inhibition on Blood Pressure, Plasma Renin Activity and Plasma Aldosterone in Essential Hypertension *1978 · 29 citations
  2. 2Use of an Angiotensin II Antagonist (Saralasin) in the Recognition of “Angiotensinogenic” Hypertension1975 · 277 citations
  3. 3Blockade and stimulation of renal, adrenal, and vascular angiotensin II receptors with 1-Sar, 8-Ala angiotensin II in normal man.1976 · 164 citations
  4. 4Reciprocal Relation between Renin Dependency and Sodium Dependency in Essential Hypertension1976 · 119 citations
  5. 5Essential Hypertension: Renin and Aldosterone, Heart Attack and Stroke1972 · 1,100 citations