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February 1, 2014Bone and Joint ResearchOpen Access

Basic science of anterior cruciate ligament injury and repair

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Authors

AKAta M. KiapourBoston Children's HospitalMMMartha M. MurrayBoston Children's Hospital

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Implication

Instructional review demonstrates advances in biological repair for anterior cruciate ligament tears, indicating potential to prevent post-traumatic osteoarthritis.

Key Points

  • To review the biological mechanisms governing anterior cruciate ligament (ACL) injury and summarize progress in biologically augmented repair techniques.
  • Synthesized findings from basic science literature and preclinical models evaluating ACL healing biology and surgical intervention strategies.
  • Assessed the limitations of standard ACL reconstruction alongside novel regenerative medicine and tissue engineering modalities.
  • Standard ACL reconstruction reliably restores gross joint stability but frequently fails to prevent the subsequent development of post-traumatic osteoarthritis.
  • Biologically augmented ACL-repair techniques show satisfactory healing and structural outcomes in preclinical investigations.

Cite This Study

Kiapour et al. (2014) studied this question.

synapsesocial.com/papers/6a726a3f3ce530166bc35073https://doi.org/10.1302/2046-3758.32.2000241
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Arthrofibrosis in acute anterior cruciate ligament reconstruction1991 · 670 citations
  2. 2Incidence of Subsequent Injury to Either Knee within 5 Years after Anterior Cruciate Ligament Reconstruction with Patellar Tendon Autograft2008 · 462 citations
  3. 3Autologous Mesenchymal Stem Cell-Mediated Repair of Tendon1999 · 548 citations
  4. 4Platelet Quantification and Growth Factor Analysis from Platelet-Rich Plasma: Implications for Wound Healing2004 · 1,101 citations
  5. 5Has Platelet‐Rich Plasma Any Role in Anterior Cruciate Ligament Allograft Healing?2009 · 213 citations