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In vitro system using highly purified Hepatitis C Virus nonstructural protein 5B expressed by a recombinant…
Design
Preclinical
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Biochemical RdRp characterization may inform HCV antiviral targets; leaves open translation to in vivo efficacy or therapy.
Characterization of the HCV NS5B protein's polymerase and RNA binding activities provides insights into viral replication mechanisms and identifies potential targets for antiviral therapy.
Ishii et al. (1999) studied this question.
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