Why the study?
Does continuous intravenous heparin infusion reduce thrombin generation markers (FPA and TAT) in patients with acute myocardial infarction?
Population
100 patients with acute myocardial infarction
Comparison
Continuous intravenous heparin infusion at a… vs No heparin treatment
Design
Cohort
Follow-up
14 days
Authors
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Transient heparin suppression of thrombin markers in AMI warrants caution after 48 hours; leaves open need for sustained antithrombotic strategies.
Does continuous intravenous heparin infusion reduce thrombin generation markers (FPA and TAT) in patients with acute myocardial infarction?
Thrombin generation remains persistently elevated for up to two weeks after acute myocardial infarction, and standard heparin infusion only transiently suppresses it for the first 48 hours.
Szczeklik et al. (1992) studied this question.
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