Why the study?
Do antiplatelet agents (aspirin, clopidogrel, abciximab) reduce platelet-induced thrombin generation as measured by endogenous thrombin potential?
Population
Blood samples from human subjects (specific demographics and sample size not stated)
Comparison
In vivo treatment with aspirin and clopidogrel… vs Untreated/baseline state
Design
Preclinical
Authors
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Hypothesis-generating for ETP as antiplatelet pharmacodynamic marker; leaves open human translation and clinical utility.
Do antiplatelet agents (aspirin, clopidogrel, abciximab) reduce platelet-induced thrombin generation as measured by endogenous thrombin potential?
The automated endogenous thrombin potential (ETP) assay is a sensitive and reproducible method for evaluating the pharmacodynamic effects of antiplatelet drugs on thrombin generation.
Wegert et al. (2002) studied this question.
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