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-Z12 (50/50 copolymer of polysulfobetaine methacrylates with 6 and 12 spacer lengths), was observed to inhibit bacterial growth completely and its activity was sustained for a long time (>3 months). Surprisingly, its antibacterial effect was found to be bactericidal, as is evident from live-dead staining of residual dead bacterial cells that can be easily released by exposing the surface to salt solution, thereby regenerating the surface. However, all of the other copolymer as well as homopolymer brushes exhibited bacteriostatic behavior. An attempt was made to understand the peculiar behavior of this particular brush composition. Nevertheless, the biocidal and also protein repellent brush did not display any cytotoxicity towards human cells, making it an ideal substrate to be used as an infection resistant biomedical implant. Animal studies further confirmed that this particular copolymeric brush modified scaffold can be a promising anti-infective wound dressing material with rapid wound healing effects as compared to the unmodified scaffold.
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Dhingra et al. (2023) studied this question.
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