Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation
Population
42 patients undergoing cardiac surgery, including 26 with sinus rhythm and 16 with chronic atrial…
Design
Cohort
Authors
Discussion
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Implication
Chronic AF remodeling features upregulated I(K1) and downregulated I(K,ACh) independent of Gβ3; leaves open causality and postoperative AF prediction.
Key Points
- This research investigates the relationship between potassium currents and G beta 3 gene status in patients with chronic atrial fibrillation and postoperative AF.
- Measured I(K1) and I(K,ACh) in atrial myocytes from 26 patients with sinus rhythm and 16 patients with chronic AF.
- Current amplitudes measured using standard patch-clamp techniques.
- G beta 3 gene status determined by PCR and restriction analysis.
- I(K1) amplitude was larger in chronic AF (10.9±1.0 pA/pF) compared to sinus rhythm (6.3±0.6 pA/pF, P<0.05).
- I(K,ACh) amplitude was smaller in chronic AF (2.9±0.7 pA/pF) than in sinus rhythm (6.3±0.7 pA/pF, P<0.05).
- Changes in I(K1) and I(K,ACh) were independent of G beta 3 gene status.
Structured PICO
P
Population
42 patients undergoing cardiac surgery, including 26 with sinus rhythm (SR) and 16 with chronic atrial fibrillation (AF >6 months).
C
Comparator
Patients in sinus rhythm (SR)
O
Outcome
Amplitudes of inward rectifier K(+) currents I(K1) and acetylcholine-activated K(+) current I(K,ACh) in atrial myocytessurrogate
Chronic atrial fibrillation is associated with upregulation of I(K1) and downregulation of I(K,ACh) currents independent of G beta 3 gene status, but these electrophysiological changes are not present prior to surgery in patients who later develop postoperative AF.
Cite This Study
Dobromir Dobrev (2002) studied this question.