Why the study?
Does therapeutic drug monitoring based on pharmacokinetic modelling improve the efficacy and control the toxicity of anticancer drugs?
Population
Patients receiving anticancer drugs
Design
Review
Authors
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May support Bayesian TDM for anticancer dosing optimization; leaves open efficacy and toxicity benefits pending prospective trials.
Does therapeutic drug monitoring based on pharmacokinetic modelling improve the efficacy and control the toxicity of anticancer drugs?
Pharmacokinetic modelling, particularly Bayesian estimation, is an effective tool for therapeutic drug monitoring to optimize dosing, control toxicity, and improve outcomes in cancer chemotherapy.
Rousseau et al. (2002) studied this question.
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