Why the study?
Venous thromboembolism is an increasingly common problem in cancer patients, especially those with lung cancer.
This case report highlights a rare instance of refractory DVT in an advanced lung cancer patient that progressed to amputation despite standard anticoagulant therapy, underscoring the importance of early diagnosis and prophylactic anticoagulation.
Reinforces VTE vigilance in lung cancer on chemotherapy; leaves open optimal prophylaxis strategies for controlled trials.
BACKGROUND: Venous thromboembolism (VTE) is a common problem in cancer patients and the incidence is increasing, especially for patients with lung cancer. Common features of these patients, like advanced stage, male gender, old age and chemotherapy, are risk factors of VTE. Here we reported a case in which the patient with lung cancer developed deep vein thrombosis (DVT) when receiving chemotherapy. CASE PRESENTATION: A 53-year-old male who was diagnosed with lung cancer with multiple metastasis developed severe DVT during chemotherapy. Despite the use of aspirin, warfarin and low molecular weight heparin (LMWH) for anticoagulant and thrombolytic therapy, the condition was still deteriorating, resulting in amputation finally. CONCLUSIONS: It's rare that the conditions of cancer patients who develop venous thromboembolism (VTE) keep deteriorating despite the administration of aspirin, warfarin and low weight molecular heparin. Both early diagnosis and prophylactic use of anticoagulants are suggested for cancer patients to improve the prognosis.
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Chen et al. (2019) studied this question.
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