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May 12, 2023Rational Pharmacotherapy in CardiologyOpen Access

Vasotoxic Effects of Anticancer Therapy: a Review of Current Data

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Why the study?

Anticancer drugs can cause severe cardiovascular complications, and data have emerged regarding their potential vasotoxic effects such as hypertension, thrombosis, and myocardial ischemia.

Does anticancer therapy cause vasotoxic effects in cancer patients?

Population

Cancer patients receiving presumably vasotoxic therapy across 12 selected studies

Design

Review of 12 selected observational retrospective and prospective studies

Authors

YVYu. A. VasyukAmerican College of CardiologyESE. Yu. ShupeninaMoscow State University of Medicine and DentistryANA. G. Nosova

Discussion

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Overview

May warrant CV monitoring in cancer patients on chemotherapy; leaves open mechanistic and preventive trials.

Structured PICO

Does anticancer therapy cause vasotoxic effects in cancer patients?

P
Population
Cancer patients receiving presumably vasotoxic therapy (based on a review of 12 selected observational retrospective and prospective studies)
I
Intervention
Anticancer therapy (chemotherapy drugs)
O
Outcome
Vasotoxic effects (progression of arterial hypertension and atherosclerosis, development of myocardial ischemia and acute coronary syndrome, formation of venous and arterial thrombosis)safety

Anticancer therapies can induce significant vasotoxic effects, highlighting the need for cardiovascular monitoring and prevention strategies in cardio-oncology.

Cite This Study

Vasyuk et al. (2023) studied this question.

synapsesocial.com/papers/6a72738826a7f98052de4e70https://doi.org/10.20996/1819-6446-2023-03-03
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardio-Oncology: Vascular and Metabolic Perspectives: A Scientific Statement From the American Heart Association2019 · 217 citations
  2. 2Thrombosis in patients with malignancy2018 · 5 citations
  3. 3Risk of Arterial Thromboembolism in Patients With Cancer2017 · 665 citations
  4. 4Cardiotoxicity of 5‐fluorouracil and capecitabine in Chinese patients: a prospective study2018 · 64 citations
  5. 5Сonsensus statement of Russian experts on the prevention, diagnosis and treatment of cardiotoxicity of anticancer therapy2021 · 82 citations