Why the study?
Does capecitabine-based chemotherapy compared to 5-FU-based chemotherapy increase the risk of cardiotoxicity in Chinese patients with malignant diseases?
Population
527 Chinese patients with malignant diseases receiving 5-fluorouracil-based or capecitabine-based…
Comparison
Capecitabine-based chemotherapy vs 5-fluorouracil (5-FU)-based chemotherapy
Design
Cohort
Follow-up
during treatment and up to 28 days of follow-up
Authors
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Capecitabine was associated with higher cardiotoxicity than 5-FU; leaves open preferential 5-FU use pending randomized confirmation.
Does capecitabine-based chemotherapy compared to 5-FU-based chemotherapy increase the risk of cardiotoxicity in Chinese patients with malignant diseases?
Capecitabine-based chemotherapy is associated with a significantly higher incidence of cardiotoxicity compared to 5-FU-based chemotherapy in Chinese cancer patients, with pre-existing cardiac disease and hypertension identified as significant risk factors.
Peng et al. (2018) studied this question.
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