Key result
Capecitabine successfully replaced 5-fluorouracil without recurrence of cardiac symptoms in a patient who developed 5-fluorouracil-induced chest pain.
Why the study?
Does capecitabine prevent recurrence of cardiac symptoms in patients with 5-fluorouracil-induced cardiotoxicity?
Population
A patient who experienced chest pain (cardiotoxicity) while on 5-fluorouracil therapy for malignancy
Comparison
Capecitabine (oral formulation of 5-fluorouracil) vs 5-fluorouracil (prior therapy)
Design
Case_report
Authors
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May support capecitabine substitution after 5-FU cardiotoxicity; leaves open prospective validation before practice change.
Case Report (n=1)
Does capecitabine prevent recurrence of cardiac symptoms in patients with 5-fluorouracil-induced cardiotoxicity?
Capecitabine may be a viable and safe alternative for patients who develop 5-fluorouracil-induced chest pain, though larger trials are needed.
Saneeymehri et al. (2015) conducted a case report in 5-fluorouracil-induced cardiotoxicity (n=1). Capecitabine vs. 5-fluorouracil was evaluated on Recurrence of cardiac symptoms. Capecitabine successfully replaced 5-fluorouracil without recurrence of cardiac symptoms in a patient who developed 5-fluorouracil-induced chest pain.
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