Population
46 patients with insulin-dependent diabetes mellitus (IDDM) and 18 age and sex-matched healthy controls
Design
Case-control
Authors
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Altered hemostatic markers in IDDM should not change practice; supports hypothesis of vascular damage-driven TFPI increase over procoagulant response.
Increased TFPI activity in IDDM patients may be driven by vascular damage and alterations in glycosaminoglycans rather than a reaction to a procoagulant state.
Leurs et al. (1997) studied this question.
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