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August 17, 2021Gynecological EndocrinologyOpen Access

Overall and bleeding-related discontinuation rates of a new oral contraceptive containing 4 mg drospirenone only in a 24/4 regimen and comparison to 0.075 mg desogestrel

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Why the study?

Progestin-only pills avoid thrombotic risks but cause poor cycle control, prompting evaluation of whether a novel drospirenone-only pill improves bleeding profiles and reduces bleeding-related discontinuations compared to desogestrel.

Does drospirenone 4 mg reduce discontinuation rates compared to desogestrel 0.075 mg in healthy women aged 18-45 years?

Population

Healthy women aged 18-45 years (858 receiving DRSP and 332 receiving DSG)

Comparison

Drospirenone (DRSP) vs desogestrel (DSG)

Design

Double-blind, double-dummy prospective phase III study

Authors

PRPedro‐Antonio RegidorTechnology Holding (United States)ECEnrico ColliUniversity of VermontSPSantiago PalaciosHeidelberg University

Discussion

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Implication

DRSP-only pill may improve adherence via better bleeding control; extends RCT evidence favoring it over other progestin-only options.

Structured PICO

Does drospirenone 4 mg reduce discontinuation rates compared to desogestrel 0.075 mg in healthy women aged 18-45 years?

P
Population
1,190 healthy women aged 18-45 years (n=858 in drospirenone group, n=332 in desogestrel group)
I
Intervention
Drospirenone 4 mg oral contraceptive in a 24/4 regimen
C
Comparator
Desogestrel 0.075 mg oral contraceptive
O
Outcome
Overall discontinuation rates and discontinuation rates due to abnormal bleedingsafety

A drospirenone-only oral contraceptive significantly reduces discontinuation rates due to abnormal bleeding compared to desogestrel.

Cite This Study

Regidor et al. (2021) studied this question.

synapsesocial.com/papers/6a7273d1febe604dd70a9d94https://doi.org/10.1080/09513590.2021.1963432
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ovarian activity and vaginal bleeding patterns with a desogestrel-only preparation at three different doses1996 · 56 citations
  2. 2Oral contraceptives and venous thromboembolism: findings in a large prospective study.1986 · 262 citations
  3. 3A double-blind study comparing the contraceptive efficacy, acceptability and safety of two progestogen-only pills containing desogestrel 75 μg/day or levonorgestrel 30 μg/day: Collaborative Study Group on the Desogestrel-containing Progestogen-only Pill1998 · 130 citations
  4. 4Progestogen-only pills and bleeding disturbances1996 · 65 citations
  5. 5Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-92011 · 616 citations