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What is the seroprevalence of postvaccination poliovirus antibodies in children vaccinated with three oral polio vaccines in Saudi Arabia?
What is the seroprevalence of postvaccination poliovirus antibodies in children vaccinated with three oral polio vaccines in Saudi Arabia?
The seropositivity rates for poliovirus types 1, 2, and 3 after three doses of oral polio vaccine were suboptimal, suggesting a need for a new vaccination strategy in Saudi Arabia.
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Suboptimal seropositivity may signal immunity gaps; hypothesis-generating for revised polio vaccination strategies in Saudi Arabia.
This is a national seroprevalence study conducted in Saudi Arabai in 1991G to determine postvaccination poliovirus antibody. Two hundred and nine children vaccinated with three oral polio vaccines at three, four, and five months of age were included in the study representing the five main regions in Saudi Arabia. Blood samples were collected at the age of nine months. Cytopathic effect (CPE) neutralization was used to determine the level of polio antibody. A dilution of 1/8th or more was defined as positive. Seventy-nine percent, 88% and 65% of the children were positive for Type 1, Type 2, and Type 3, respetively. Development of a new strategy of polio vaccination is needed.
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Khalil et al. (1994) studied this question.
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