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This review highlights the growing evidence for an immune-mediated pathogenesis in a subset of patients with idiopathic dilated cardiomyopathy, emphasizing the role of specific autoantibodies and myosin as an antigen.
Idiopathic dilated cardiomyopathy is a chronic heart muscle disorder of unknown etiology, but experimental and clinical evidence is accumulating that points to an immune pathogenesis in a subset of patients, and to the potential importance of myosin as an antigen. Most recent developments include evidence of cardiac- and disease-specific autoantibodies in a proportion of patients with dilated cardiomyopathy and their relatives, and the identification of immunogenic epitopes.
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Goldman et al. (1995) studied this question.
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