Desmopressin in the treatment of nocturnal enuresis in patients with spina bifida

Results Thirteen patients, 5 males and 8 females were treated with Desmopressin and they were evaluated. Nine patients were operated beforehand: 8 patients were treated with a bladder augmentation and bladder neck sling suspension and one boy had an urethral valve resection. All 13 patients were dry during daytime and 3 of them even did not need antimuscarinic agents. All 13 patients had normal kidney function and urodynamic studies showed compliant bladders without overactive contractions. During nighttime however they wetted their beds. Desmopressin (0,4 mg a.n.) was successful in 12 patients: they became completely dry during the night. One of them however relapsed and he will be treated with an alarm clock system as an adjuvant therapy.