August 1, 1997Journal of Biological ChemistryOpen Access

Isoform-specific Interaction of the Myosin-binding Proteins (MyBPs) with Skeletal and Cardiac Myosin Is a Property of the C-terminal Immunoglobulin Domain

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Population

Chicken and human skeletal MyBP-H and MyBP-C cDNAs and proteins

Design

Preclinical

Authors

TAT N AlyonychevaCornell University TMTakashi MikawaBay Institute FRFernando C. ReinachUniversidade de São Paulo

Discussion

Member takes

Implication

Localizes myosin binding to C-terminal Ig domain in MyBP-C; leaves open roles in human sarcomere regulation and cardiomyopathy.

Structured PICO

Population

Chicken and human skeletal MyBP-H and MyBP-C cDNAs and proteins

Intervention

Biochemical characterization including alpha-chymotryptic and tryptic digestion, and binding reactions

Outcome

Mapping of the myosin binding domain and determination of binding stoichiometrysurrogate

The study identifies that the myosin binding site in cardiac MyBP-C and skeletal MyBP-H is located in a homologous C-terminal immunoglobulin domain, providing molecular insights into muscle filament assembly.

Cite This Study

Alyonycheva et al. (1997) studied this question.

synapsesocial.com/papers/6a727e03febe604dd70aa23e https://doi.org/10.1074/jbc.272.33.20866

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Isoform-specific Interaction of the Myosin-binding Proteins (MyBPs) with Skeletal and Cardiac Myosin Is a Property of the C-terminal Immunoglobulin Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isoform-specific Interaction of the Myosin-binding Proteins (MyBPs) with Skeletal and Cardiac Myosin Is a Property of the C-terminal Immunoglobulin Domain

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider