Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 1, 1986Molecular and Cellular BiologyOpen Access

Characterization of a Family of Gamma-Ray-Induced CHO Mutants Demonstrates that the ldlA Locus Is Diploid And Encodes the Low-Density Lipoprotein Receptor

View Full Paper
Ask AI
Bookmark
Share

Population

Chinese hamster ovary (CHO) cells (wild-type and 3 gamma-ray-induced ldlA mutants)

Comparison

Gamma-irradiation and molecular analysis using… vs Wild-type CHO cells

Design

Preclinical

Authors

RSRobert SegeTufts UniversityKKKaren KozarskyIo Therapeutics (United States)MKMonty KriegerMassachusetts Institute of Technology

Discussion

Loading...

Member takes

Implication

No immediate clinical impact; leaves open translation of ldlA diploidy to human LDL receptor disorders.

Structured PICO

P
Population
Chinese hamster ovary (CHO) cells (wild-type and 3 gamma-ray-induced ldlA mutants)
I
Intervention
Gamma-irradiation and molecular analysis using nucleic acid and antibody probes
C
Comparator
Wild-type CHO cells
O
Outcome
Characterization of the ldlA locus (expression, structure, and function of LDL receptors and gene deletions)surrogate

This basic science study confirms that the ldlA locus in CHO cells is diploid and encodes the LDL receptor, providing foundational knowledge for LDL receptor genetics.

Cite This Study

Sege et al. (1986) studied this question.

synapsesocial.com/papers/6a727e4335aa2c282ce3487chttps://doi.org/10.1128/mcb.6.9.3268-3277.1986
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unusual forms of low density lipoprotein receptors in hamster cell mutants with defects in the receptor structural gene.1986 · 58 citations
  2. 2Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.1978 · 1,138 citations