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Polyamine-containing bolaamphiphiles bind and compact DNA to form well-defined assemblies that resist nuclease attack and efficiently transfect Chinese hamster ovary cells. Nonspecific uptake is reduced by the incorporation of a low percentage of polyethylene glycol bolaamphiphile and the targeted transfection of a human T cell line has been demonstrated using an internalizing anti-CD3-antibody/bolaamphiphile conjugate incorporated at 0.004 % into the supramolecular array.
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Eaton et al. (2000) studied this question.
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