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September 13, 1979New England Journal of Medicine

Prevention of Thrombosis in Patients on Hemodialysis by Low-Dose Aspirin

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Why the study?

Does low-dose aspirin (160 mg per day) prevent thrombosis in patients on chronic hemodialysis?

Population

44 patients on chronic hemodialysis

Comparison

Aspirin 160 mg per day vs Placebo

Design

RCT, randomized, double-blind

Follow-up

mean of nearly five months

Authors

HHHerschel R. HarterLouisiana State UniversityJBJohn W. BurchFederation UniversityPMPhilip W. MajerusKagoshima University

Discussion

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Overview

Supports aspirin for thrombosis prevention in hemodialysis; confirms benefit in this high-risk population.

Structured PICO

Does low-dose aspirin (160 mg per day) prevent thrombosis in patients on chronic hemodialysis?

P
Population
44 patients on chronic hemodialysis
I
Intervention
Aspirin 160 mg per day
C
Comparator
Placebo
O
Outcome
Occurrence of thrombihard clinical

Low-dose aspirin (160 mg per day) significantly reduces the incidence of thrombosis in patients on chronic hemodialysis.

Cite This Study

Harter et al. (1979) studied this question.

synapsesocial.com/papers/6a727f77a2d7cf2e39c2f3b7https://doi.org/10.1056/nejm197909133011103
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Aspirin Prophylaxis of Venous Thromboembolism after Total Hip Replacement1977 · 344 citations
  2. 2The mechanism of the effect of aspirin on human platelets. I. Acetylation of a particulate fraction protein.1975 · 865 citations
  3. 3A Randomized Controlled Trial of Acetyl Salicyclic Acid in the Secondary Prevention of Mortality from Myocardial Infarction1974 · 519 citations
  4. 4Acetylation of prostaglandin synthase by aspirin.1975 · 1,014 citations
  5. 5Inhibition of platelet prostaglandin synthetase by oral aspirin.1978 · 557 citations