Why the study?
Does MK-0448 prolong atrial refractoriness and terminate atrial fibrillation in preclinical models and healthy human subjects?
Population
In vitro models, normal anesthetized dogs, conscious dog heart failure model, and healthy human subjects
Comparison
MK-0448 (a novel I inhibitor), including bolus… vs Vehicle controls (in preclinical studies)
Design
Preclinical
Authors
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Human data refute dog-model efficacy of MK-0448; leaves open whether I(Kur) inhibition merits further AF study.
Does MK-0448 prolong atrial refractoriness and terminate atrial fibrillation in preclinical models and healthy human subjects?
MK-0448, an I(Kur) inhibitor, failed to prolong atrial refractoriness in humans despite efficacy in preclinical models, suggesting limited therapeutic value for atrial fibrillation prevention.
Pavri et al. (2012) studied this question.
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