Mechanism of EV71-induced neurological syndrome

In recent years, the incidence of hand foot and mouth disease has been on the rise with severe and fatal cases often caused by enterovirus 71(EV71) infection.EV71 possesses powerful ability of neural invasion, and severe nerve damage is one of the signs of its infection, including aseptic meningitis, poliomyelitis-like paralysis, acute brainstem encephalitis and other severe neurological syndrome, which may make the neurological sequelae difficult to reverse, and even death.At present, EV71 has become one of the main viral pathogens causing central nervous system diseases in infants and young children, which seriously threatens the life and health of infants and young children.The pathogenesis of EV71 has not yet been totally clarified.Clinically, it mainly focuses on symptomatic supportive care and prevention of complications.This article starts with the introduction of the etiology of EV71 and briefly describes its relative pathogenesis with the view of providing new ideas for its intervention at the level of primary prevention.