Why the study?
Evidence suggests body fat distribution may play a more prominent role than total body fat in cerebrovascular risk prediction, but causal associations with BMI-independent adipose profiles remained unclear.
Does genetic predisposition to higher gluteofemoral adipose tissue volume reduce the risk of ischemic stroke and its subtypes?
Population
UK Biobank participants with variants associated with BMI-independent adipose tissue volumes
Comparison
Genetically predicted VAT vs ASAT vs GFAT volumes
Design
Univariable and multivariable Mendelian randomization study
Authors
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Highlights potential causal role of fat distribution in stroke; leaves open targeted prevention trials.
Does genetic predisposition to higher gluteofemoral adipose tissue volume reduce the risk of ischemic stroke and its subtypes?
Genetic predisposition to higher gluteofemoral adipose tissue volume is associated with a reduced risk of ischemic stroke and coronary artery disease, suggesting a protective role of this specific fat distribution.
Myserlis et al. (2025) studied this question.