Why the study?
Does a propofol/ketamine combination improve sedation depth and safety compared to propofol alone in patients undergoing procedural sedation for fracture manipulation?
Population
28 patients undergoing procedural sedation for fracture manipulation in a Level 1 trauma center emergency…
Comparison
Propofol/ketamine combination with a target dose… vs Propofol alone with a target dose of 0.5 to 1.5…
Design
RCT, randomized
Authors
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Propofol-ketamine may limit hypotension during procedural sedation; confirms RCT hemodynamic and dosing benefits versus propofol alone.
Does a propofol/ketamine combination improve sedation depth and safety compared to propofol alone in patients undergoing procedural sedation for fracture manipulation?
The combination of propofol and ketamine for procedural sedation in the emergency department results in less hypotension and lower propofol requirements compared to propofol alone.
Phillips et al. (2010) studied this question.
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