Key result
Trimetaphan reduces infarct size by ~49% in a hypertensive patient when started after pain onset.
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datal'3 to be too extensive to be explained only by salvation of the cells in the jeopardized zone. Concerning the data on treated pa- tients the treatment was started 13 hours after the onset of chest pain,1' 2 and it is hard to understand that the effect of treatment at this stage can be so extensive. According to the computed curves most of the irreversible damage is already done, and the cells that are candidates for salvage at this point seem to be only a small por- tion of the total. Yet the authors describe a reduction of infarct size from 53 CPK gram-equivalents to 27 in the reported case of trimet- aphane treatment in a hypertensive patient.
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J G Greenwald (1977) conducted a letter in Myocardial infarction and hypertension. Trimetaphane was evaluated on Infarct size (CPK gram-equivalents). Trimetaphane treatment started 13 hours after chest pain onset was reported to reduce infarct size from 53 to 27 CPK gram-equivalents in a hypertensive patient.
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