Why the study?
Model-based experimental designs minimize experimental effort while maximizing analyzable data, motivating an initial mathematical model of the maturation process of tissue-engineered heart valves.
Answers are grounded in this paper and cite their sources.
A mathematical model of biohybrid heart valve maturation identifies cell diffusion parameters as critical targets for experimental focus.
Model-based experimental designs minimize the experimental effort while maximizing the amount of analyzable experimental data. In this paper, an initial mathematical model of the spatially distributed maturation process of tissue engineered heart valves is developed for a model-based experimental design. The model contains the state variables cell amount, collagen concentration and elastin concentration. Based on the developed model, a variance-based sensitivity analysis using Sobol’s method is performed. The results indicate that all model parameters influence the model solution, while the variance of the parameters related to cell diffusion comprises an exceeding influence. Consequently, corresponding experiments should especially focus on those parameters.
No takes yet. Share an insight, caveat, or question.
Voß et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: