October 23, 2015Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materialsOpen Access

A computational analysis of cell-mediated compaction and collagen remodeling in tissue-engineered heart valves

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Population

Computational model of tissue-engineered heart valves (TEHVs)

Design

Preclinical

Authors

SLSandra LoerakkerEindhoven University of Technology TRTommaso RistoriEindhoven University of Technology FBFrank Frank BaaijensStructural Heart Disease

Discussion

Member takes

Implication

Model predictions favor aortic over pulmonary conditions for engineered valves; hypothesis-generating pending in vivo validation.

Structured PICO

Population

Computational model of tissue-engineered heart valves (TEHVs)

Intervention

Simulated dynamic pulmonary and aortic pressure conditions

Outcome

Remodeling process and risk of valvular insufficiency due to leaflet retractionsurrogate

Computational modeling indicates that tissue-engineered heart valves undergo more favorable and stable remodeling under aortic rather than pulmonary pressure conditions.

Cite This Study

Loerakker et al. (2015) studied this question.

synapsesocial.com/papers/6a87d3f96e1dca10b7bb5ed9 https://doi.org/10.1016/j.jmbbm.2015.10.001

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A computational analysis of cell-mediated compaction and collagen remodeling in tissue-engineered heart valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A computational analysis of cell-mediated compaction and collagen remodeling in tissue-engineered heart valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Also Consider