Key result
Explanted tissue-engineered heart valve materials showed successful recellularization and mechanical behavior similar to native tissues after 6 months of implantation in a rat subdermis model.
Why the study?
Commercially available heart valves have limitations like lack of remodeling, and in vitro testing cannot sufficiently characterize the evolving mechanical behavior of recellularizing tissue-engineered heart valves in vivo.
Population
Tissue-engineered heart valve material in a rat subdermis model
Comparison
TEHV material before vs after 6 months of implantation and native tissues
Design
In silico finite element analysis following an in vivo animal model
Follow-up
6 months
Authors
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Supports recellularization in engineered valves; hypothesis-generating from rat subdermal model and requires large-animal orthotopic validation.
A tissue-engineered heart valve material demonstrated successful recellularization and mechanical properties similar to native tissue after 6 months in a rat subdermis model.
Noble et al. (2019) studied this question. Tissue-engineered heart valve (TEHV) material vs. Native tissues and pre-implantation implants was evaluated on Mechanical behavior (maximum principal stresses and strains) and recellularization. Explanted tissue-engineered heart valve materials showed successful recellularization and mechanical behavior similar to native tissues after 6 months of implantation in a rat subdermis model.
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