Why the study?
Does a tissue-engineered aortic valve prevent graft rejection and calcification compared to cryopreserved valves in a sheep model?
Population
Sheep model for orthotopic aortic valve replacement (n=9)
Comparison
Tissue-engineered aortic valve created from… vs Cryopreserved aortic valve (CPV) allografts
Design
Preclinical
Follow-up
3 months
Authors
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Does not support clinical adoption; leaves open translation of TEVs to human valve replacement.
Does a tissue-engineered aortic valve prevent graft rejection and calcification compared to cryopreserved valves in a sheep model?
Tissue-engineered aortic valves based on decellularized allografts show excellent short-term function and resistance to degeneration in a sheep model, highlighting their potential for future clinical use.
Tudorache et al. (2013) studied this question.
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