Key result
Re-endothelialization of decellularized valves with autologous endothelial cells improved total endothelial cell valve coverage at 3 months compared to decellularized valves alone.
Why the study?
Does in vitro re-endothelialization of decellularized pulmonary valves improve endothelial coverage and function compared to decellularized valves alone in an ovine model?
Population
Ovine pulmonary valves (n=21) implanted into lambs
Comparison
In vitro re-endothelialization of… vs Detergent-decellularized pulmonary valves…
Design
Preclinical
Follow-up
1 and 3 months
Authors
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Supports preclinical optimization of cell-seeded valves; leaves open translation to human durability or thrombosis outcomes.
Does in vitro re-endothelialization of decellularized pulmonary valves improve endothelial coverage and function compared to decellularized valves alone in an ovine model?
In vitro re-endothelialization of decellularized heart valves with autologous endothelial cells improves endothelial coverage and reduces thrombotic formations after implantation in an ovine model.
Lichtenberg et al. (2006) studied Tissue-engineered heart valves (n=14). Re-endothelialized pulmonary valves vs. Decellularized pulmonary valves was evaluated on Valve function, morphological changes, and cellular composition. Re-endothelialization of decellularized valves with autologous endothelial cells improved total endothelial cell valve coverage at 3 months compared to decellularized valves alone.
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