Key result
Autologous cell-seeded pulmonary valves yield ~83% normal function in sheep vs unseeded controls.
Why the study?
Does tissue engineering of allogenic acellular matrix conduits with autologous cells improve in vivo function and tissue restitution in a sheep model of pulmonary valve transplantation?
Population
Sheep model of orthotopic pulmonary valve conduit transplantation (n=10)
Comparison
Tissue-engineered pulmonary heart valves vs Unseeded allogenic acellular control valves
Design
Preclinical
Follow-up
up to 3 months
Authors
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Supports further development of autologous-seeded valves; leaves open translation from sheep models to patients.
Does tissue engineering of allogenic acellular matrix conduits with autologous cells improve in vivo function and tissue restitution in a sheep model of pulmonary valve transplantation?
Absolute Event Rate: 83.3% vs 75%
In vitro tissue engineering using acellular matrix conduits seeded with autologous cells leads to successful in vivo reconstitution of viable heart valve tissue in a sheep model.
Steinhoff et al. (2000) studied Pulmonary heart valve replacement (n=10). Tissue-engineered allogenic acellular matrix scaffolds seeded with autologous cells vs. Unseeded allogenic acellular control valves was evaluated on Normal in vivo function up to 3 months. Tissue-engineered pulmonary heart valves seeded with autologous cells showed normal function in 83.3% of sheep compared to 75.0% with unseeded control valves at 3 months.
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