Why the study?
Does dynamic bioreactor conditioning improve the mechanical properties and tissue organization of human tissue-engineered heart valves compared to static culturing?
Population
Tissue-engineered human heart valves based on human saphenous vein cells and a rapid degrading synthetic…
Comparison
Conditioning using bioreactors for up to 4 weeks vs Static culturing
Design
Preclinical
Follow-up
up to 4 weeks
Authors
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Bioreactor conditioning advances preclinical valve maturation; leaves open translation to durable human aortic replacements.
Does dynamic bioreactor conditioning improve the mechanical properties and tissue organization of human tissue-engineered heart valves compared to static culturing?
Dynamic bioreactor conditioning improves the mechanical properties of human tissue-engineered heart valves, representing a step toward living aortic valve replacements.
Mol et al. (2006) studied this question.