Why the study?
Does transcatheter implantation of homologous tissue-engineered heart valves provide long-term in vivo functionality and self-repair capacity in a sheep model?
Population
Sheep model (n=12) for pulmonary valve replacement
Comparison
Transcatheter implantation of homologous… vs Identical not implanted TEHVs for tissue…
Design
Preclinical
Follow-up
up to 24 weeks
Authors
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Supports ongoing preclinical development; leaves open clinical translation and long-term durability in humans.
Does transcatheter implantation of homologous tissue-engineered heart valves provide long-term in vivo functionality and self-repair capacity in a sheep model?
Homologous off-the-shelf tissue-engineered heart valves demonstrate feasibility, long-term functionality, and self-repair capacity in a preclinical sheep model.
Driessen‐Mol et al. (2013) studied this question.
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