Key result
A finite-element model demonstrated that computed preferred collagen fiber directions run from commissure to commissure, showing strong resemblance to experimental data from native aortic valves.
Population
Finite-element (FE) model of tissue-engineered aortic heart valves
Comparison
Mechanical loading condition vs Experimental data from native aortic heart valves
Design
Preclinical
Authors
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Supports strain-directed remodeling in engineered valves; hypothesis-generating and leaves clinical translation open.
A finite-element model demonstrates that mechanically induced collagen fiber remodeling in tissue-engineered aortic valves aligns with principal strain directions, resembling native valves.
Driessen et al. (2003) studied Tissue-engineered aortic heart valves. Finite-element (FE) model of mechanically induced collagen fiber remodeling was evaluated on Computed preferred fiber directions and collagen content. A finite-element model demonstrated that computed preferred collagen fiber directions run from commissure to commissure, showing strong resemblance to experimental data from native aortic valves.
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