March 1, 2000Journal of Veterinary Medicine Series B

A Sequential Study of Experimental Infection of Pigs with Porcine Circovirus and Porcine Parvovirus: Immunostaining of Cryostat Sections and Virus Isolation

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Population

1-day-old piglets

Comparison

Inoculation with porcine circovirus 2 and/or… vs Single infection vs co-infection

Design

Preclinical

Follow-up

up to 26 days post-inoculation

Authors

GAGordon AllanQueen's University Belfast FMF. McNeillyQueen's University Belfast BMBrian MeehanMcGill University Health Centre

Discussion

Member takes

Implication

May worsen lesions in co-infected piglets; hypothesis-generating for viral synergy, with no clinical translation yet.

Structured PICO

Population

1-day-old piglets

Intervention

Inoculation with porcine circovirus 2 (PCV2) and/or porcine parvovirus (PPV)

Comparator

Single infection (PCV2 alone or PPV alone) vs co-infection

Outcome

Sequential tissue distribution of virus (via virus isolation and immunofluorescence) and histopathological changessurrogate

Co-infection with PCV2 and PPV in piglets exacerbates histopathological lesions and increases viral antigen distribution compared to single infections.

Cite This Study

Allan et al. (2000) studied this question.

synapsesocial.com/papers/6a72896e35aa2c282ce34d74 https://doi.org/10.1046/j.1439-0450.2000.00364.x

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A Sequential Study of Experimental Infection of Pigs with Porcine Circovirus and Porcine Parvovirus: Immunostaining of Cryostat Sections and Virus Isolation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Sequential Study of Experimental Infection of Pigs with Porcine Circovirus and Porcine Parvovirus: Immunostaining of Cryostat Sections and Virus Isolation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider