Population
Three-dimensional prolate spheroidal finite-element model of the hypertrophied mouse left ventricle with…
Comparison
Focally disarrayed septal myocardium modeled by… vs Normal regions within the model
Design
Preclinical
Authors
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Supports myofiber disarray as contributor to regional RV dysfunction in HCM model; leaves open human translation.
Computational modeling suggests that regional dysfunction in hypertrophic cardiomyopathy may be partly explained by structural defects like myofiber dispersion and reduced sarcomere length.
Usyk et al. (2001) studied this question.
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