Why the study?
Does pioglitazone improve adipose tissue natriuretic peptide receptor expression and insulin sensitivity in subjects with type 2 diabetes mellitus?
Population
Subjects with a wide range of BMI and glucose tolerance and subjects with type 2 diabetes mellitus
Comparison
Pioglitazone for 12 weeks vs Placebo
Design
RCT, randomized
Follow-up
12 weeks
Authors
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NP receptor expression in adipose/muscle may associate with obesity and glucose intolerance; leaves open causal or therapeutic relevance.
Does pioglitazone improve adipose tissue natriuretic peptide receptor expression and insulin sensitivity in subjects with type 2 diabetes mellitus?
Pharmacological improvement of insulin sensitivity with pioglitazone in type 2 diabetes is associated with increased adipose tissue natriuretic peptide receptor ratio.
Kováčová et al. (2016) studied this question.
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