Key result
Protein C administration resolves hypercoagulability in ~100% of DIC patients without adverse effects.
Case Report (n=3)
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The therapeutic effect of highly purified protein C (PC) or activated protein C (APC) on three patients with disseminated intravascular coagulation (DIC) was tested. In two out of three cases, although therapeutic dose of heparin was not effective, PC or APC administration significantly improved the hypercoagulable state. In one case with acute leukemia who developed DIC with the severe gastrointestinal bleeding, APC corrected the hypercoagulable state without aggravating bleeding. These findings suggested that PC and/or APC might be effective in correcting hypercoagulable state without any adverse effect.
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Okajima et al. (1990) conducted a case report in Disseminated intravascular coagulation (DIC) (n=3). Highly purified protein C (PC) or activated protein C (APC) was evaluated on Correction of hypercoagulable state. Protein C or activated protein C administration improved or corrected the hypercoagulable state in 3 of 3 patients with disseminated intravascular coagulation without adverse effects.
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