Ether-treated extracts of 7 CS7BL lymphosarcomas induced by 3 different chemical carcinogens, urethan (Ur), N-nitrosomethylurea (NMU) or 7,12-dimethylbenz[a]anthracene (DMBA), were tested by immunodiffusion for the presence of group-specific antigens and all were found positive. Direct cytotoxic tests and absorption tests with a murine anti-G serum and a rat antiradiation leukemia virus (RadLV) serum, using 9 other Ur, NMU, or DMBA-induced CS7BL lymphomas, demonstrated the presence of common cell-surface, virus-related antigens on the virus-induced E♂G2 leukemia, the RadLV lymphoma, and the chemically induced lymphomas. An antiserum raised in CS7BL against Ur-induced C3Hf or BALB/c lymphomas exhibited a complement-dependent cytotoxic activity against 21 of 22 CS7BL lymphomas induced by the 3 different carcinogens, against the EL4 leukemia but not against the virus-induced E♂G2 leukemia. The E♂G2 leukemia also failed to absorb completely the specific cytotoxicity of the entlehemlcally induced lyrmphomas antiserum. CS7BL multiparous or antiembryo sera exerted a complement-dependent cytotoxicity on the chemically induced lymphomas but not on the E♂G2 leukemia. Thus carcinogeninduced lymphosarcomas, in addition to Gross virus-related antigens, possess tumor-specific, cell-surface, cross-reacting antigens not related to the virus, which may represent modified expressions of cellular genetic information and/or a retrogenetic expression.
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Colnaghi et al. (1973) studied this question.
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