Beneficial effects of antioxidants and l -arginine on oxidation-sensitive gene expression and endothelial NO synthase activity at sites of disturbed shear stress
Why the study?
Does cotreatment with antioxidants and l-arginine improve eNOS expression and reduce oxidation-sensitive gene perturbation in models of disturbed shear stress?
Population
Human endothelial cells exposed to shear stress in vitro and hypercholesterolemic low-density lipoprotein…
Comparison
Antioxidants and l-arginine vs No intervention (implied control)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Antioxidants plus l-arginine may mitigate turbulent shear stress effects in models; leaves open clinical translation for endothelial protection.
Structured PICO
Does cotreatment with antioxidants and l-arginine improve eNOS expression and reduce oxidation-sensitive gene perturbation in models of disturbed shear stress?
P
Population
Human endothelial cells exposed to shear stress in vitro and hypercholesterolemic low-density lipoprotein receptor knockout (LDLR(-/-)) mice in vivo
I
Intervention
Antioxidants and l-arginine
C
Comparator
No intervention (implied control)
O
Outcome
Endothelial NO synthase (eNOS) expression and oxidation-sensitive gene perturbation (activities of redox-transcription factors ELK-1, p-Jun, and p-CREB)surrogate
Antioxidants and l-arginine can prevent atherogenic effects induced by turbulent shear stress by modulating redox-transcription factors and eNOS expression in preclinical models.
Cite This Study
Nigris et al. (2003) studied this question.