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In a controlled study, benzodiazepine treatment was gradually discontinued from a group of elderly nursing home residents. In comparison with similar residents who continued on benzodiazepines, measures of memory and cognitive functioning showed significant improvement following discontinuance. There was no associated increase in anxiety, agitation, or sleeplessness. These data are consistent with previous observations suggesting that benzodiazepines impair cognitive function in the elderly and further indicate that such impairment is reversible upon benzodiazepine discontinuance.
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Salzman et al. (1992) studied this question.
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