Key result
MAP kinase pathways drive cardiac development and remodeling, showing conflicting protective versus detrimental roles.
Why the study?
The functional roles of specific MAP kinases in cardiac pathological processes remain controversial, raising questions about their therapeutic targeting in heart diseases.
Design
Review of recent studies on MAP kinase subfamilies in cardiac development and disease
Authors
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Animal data on MAP kinases in remodeling remain hypothesis-generating; human trials needed before any therapeutic consideration.
This review summarizes the complex and sometimes controversial roles of MAP kinase pathways (ERK1/2, JNK, p38, ERK5) in cardiac development, hypertrophy, and survival.
Yibin Wang (2007) conducted a review in Heart diseases and cardiac development. MAP kinase pathways (ERK1/2, JNK, p38, and ERK5) was evaluated. MAP kinase pathways play diverse roles in cardiac development and pathological remodeling, though controversies remain regarding whether specific MAP kinases act as detrimental promoters or protectors.
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