Why the study?
Does topical lidocaine improve hemodynamics after microsurgical anastomosis in a rat model?
Population
30 rats undergoing femoral artery severing and microsurgical anastomosis
Comparison
Topical 1% lidocaine applied to the vessels vs Topical physiologic saline applied to the vessels
Design
Preclinical, Randomized, Blind study
Follow-up
10 minutes
Authors
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Hypothesis-generating for topical lidocaine in microsurgical models; human trials required before any clinical consideration.
Does topical lidocaine improve hemodynamics after microsurgical anastomosis in a rat model?
Topical application of 1% lidocaine minimizes the adverse hemodynamic effects and reduction in blood flow following microsurgical anastomosis in a rat model.
Blair et al. (1981) studied this question.
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