Why the study?
Do various nonpharmacological and pharmacological interventions decrease aortic stiffness in humans?
Do various nonpharmacological and pharmacological interventions decrease aortic stiffness in humans?
A wide range of lifestyle modifications and pharmacological therapies have demonstrated efficacy in reducing aortic stiffness, a key predictor of cardiovascular morbidity.
Therapies for aortic stiffness lack RCT confirmation; leaves open targeted interventions pending prospective trials.
Aortic stiffness (AS) is an important predictor of cardiovascular morbidity in humans. The present review discusses the possible pathophysiological mechanisms of AS and focuses on a survey of different therapeutic modalities for decreasing AS. The influence of several nonpharmacological interventions is described: decrease body weight, diet, aerobic exercise training, music, and continuous positive airway pressure therapy. The effects of different pharmacological drug classes on AS are also discussed: antihypertensive drugs-renin-angiotensin-aldosterone system drugs, beta-blockers, alpha-blockers, diuretics, and calcium channel blockers (CCBs)-advanced glycation end product cross-link breakers, statins, oral anti-diabetics, anti-inflammatory drugs, vitamin D, antioxidant vitamins, and endothelin-1 receptor antagonists. All of these have shown some effect in decreasing AS.
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Hussein et al. (2016) studied this question.
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